The course of therapy should be at least seven weeks. In this case, the first 6 days should be taken once 150 mg of the drug, for this purpose use the appropriate number of tablets, which are of different dosages.
Starting from day 7, take 150 mg of the drug twice a day. Tablets are not recommended to be chewed and crushed, washed down with half a glass of water. In the second week of using the drug, you need to decide on the day when smoking is stopped, the dosage of the tablets is not changed after that, continue to take them in the same mode. The maximum single dosage of tablets is 450 mg, they are taken strictly once a day at the same time, preferably in the morning. In severe cases, the dosage is increased by 3 days of treatment or after 2 weeks by one hundred milligrams.
If a person has renal insufficiency, it is recommended to begin therapy with a minimum dosage of 150 mg per day, since the active substance has the ability to accumulate in the body.
With liver pathologies, the time between taking the drug should be increased, in this case, the tablets are taken once every 2 days at a dosage of 150 mg.