Instruction Desyrel 25mg & 100mg


The drug has antidepressant (thymoleptic) effect, combined with anxiolytic and tranquilizing effect, as well as with the sedative effect. Effective for depression which is combined with insomnia.

Desyrel antidepressant:

  • Applied with different forms of depression
  • Copes with anxiety, tension
  • For insomnia
  • Antidepressant
  • Seratonin Reuptake Antagonist
  • Has a hypnotic effect
  • Deep and deep sleep
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Desyrel is used for treating depression. It may also be used for relief of an anxiety disorder (eg, sleeplessness, tension), chronic pain. Desyrel is an antidepressant. It is thought to increase the activity of one of the brain chemicals (serotonin), which helps elevate mood.

Use Desyrel as directed by your doctor.

  • Take Desyrel shortly after a meal or light snack.
  • It may take 1 to 4 weeks for Desyrel to work. Do not stop taking Desyrel without checking with your doctor.
  • If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up. If more than one dose is missed, restart medication and advise your doctor or pharmacist at your next appointment.

Ask your health care provider any questions you may have about how to use Desyrel.

Active Ingredient: Trazodone

  • Desyrel may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Desyrel with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Desyrel; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Tell your doctor or dentist that you take Desyrel before you receive any medical or dental care, emergency care, or surgery.
  • Desyrel should not be used in children younger 6 years; safety and effectiveness in these children have not been confirmed.
  • Desyrel may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems, such as impotence. Contact your doctor right away if this happens.
  • Pregnancy and breast-feeding: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Desyrel while you are pregnant. Desyrel is found in breast milk. If you are or will be breast-feeding while you use Desyrel, check with your doctor. Discuss any possible risks to your baby.

Frequently asked questions

Depression is a mental disorder that manifests itself as a steady decrease in mood, motor inhibition and impaired thinking.

Depression sometimes manifests itself very harshly, most often you are worried about more than 2 weeks:

– longing, suffering, depressed, depressed mood, despair

– anxiety, feeling of internal tension, expectation of trouble

– guilt, frequent self-incrimination

– dissatisfaction with oneself, reduced self-confidence, reduced self-esteem

– decrease or loss of the ability to experience the pleasure of previously pleasant activities

– reduced interest in the environment

– loss of ability to experience any feelings (in cases of deep depression)

– depression is often combined with anxiety about the health and fate of loved ones, as well as with the fear of appearing untenable in public places

Depression sometimes manifests itself very harshly, most often you are worried about more than 2 weeks:

– sleep disorders (insomnia, drowsiness)

– changes in appetite (loss or overeating)

– violation of bowel function (constipation)

– reduced sexual needs

– decrease in energy, increased fatigue at usual physical and intellectual loadings, weakness

– pain and a variety of unpleasant sensations in the body (for example, in the heart, in the stomach, in the muscles)

Depression sometimes manifests itself very harshly, most often you are worried about more than 2 weeks:

– passivity, difficulty of engaging in purposeful activity

– avoidance of contacts (tendency to solitude, loss of interest in other people)

– refusal of entertainment

– alcoholism and substance abuse, providing temporary relief

Depression sometimes manifests itself very harshly, most often you are worried about more than 2 weeks:

– difficulty concentrating, concentrating

– decision making difficulties

– the predominance of dark, negative thoughts about yourself, about your life, about the world as a whole

– a dark, pessimistic vision of the future with a lack of perspective, thoughts about the meaninglessness of life

– thoughts of suicide (in severe cases of depression)

– having thoughts about your own uselessness, insignificance, helplessness

– slow thinking

If the disease is not diagnosed, do not start on time to heal, it will lead to many negative consequences. Consider the danger of depression.

  1. The dominance of negative emotions.
  2. The lack of desire to learn something new, start dating, etc.
  3. Problems with communication in personal and professional life.
  4. The emergence of previously unnoticed phobias and fears (often, for example, confined space).
  5. Decreased mental abilities.
  6. Decrease in libido, other problems in sexual life.
  7. The prevalence of feelings of hopelessness and helplessness in many situations.
  8. The trigger mechanism for the emergence of such diseases: diabetes, heart disease, migraines and headaches, malignant tumors, obesity, neuroses and panic attacks, erictal dysfunction, infertility, exacerbation of chronic diseases.
  9. Drug, tobacco, alcohol addiction.
  10. The most serious

Proper therapy allows in most cases, completely get rid of the symptoms of depression. Depression requires treatment from specialists. The main class of drugs for the treatment of depression are antidepressants.

Currently, there are various drugs in this group, of which tricyclic aptidepressants – Desyrel and have been used since the late 50s.

The tool has a pronounced anti-depressive effect, has a tranquilizing and anxiolytic effect.

The active substance eliminates insomnia, fear, affective tension, myalgia, headache and palpitations, reduces sweating, eliminates anxiety.

In patients with depression during treatment with the agent, an improvement in the quality and duration of sleep, the restoration of the physiological structure of the process was observed.

The drug is very affordable and the cost depends on the packaging. Find out the cost?

Trazodone-based medications are prescribed:

  • for treatment of psychotic, neurotic, endogenous, somatogenic depression, if the disease is accompanied by anxiety, loss of appetite, sleep, agitation or lethargy, decreased libido, fatigue, suicidal thoughts;
  • with bulimia;
  • for the treatment of kleptomania;
  • patients with phobias, panic attacks and anxiety;
  • with benzodiazepine drug dependence;
  • to eliminate acute alcohol withdrawal;
  • with impotence, reducing sexual desire;
  • as a prophylactic agent for migraine;
  • to eliminate pain in diabetic neuropathy.

Tablets can not be used:

  • with allergy to trazodone;
  • children up to 6 years;
  • in case of intoxication with sleeping pills or alcohol;
  • pregnant women;
  • during lactation.

Caution is recommended to observe:

  • during recovery after myocardial infarction;
  • with low blood pressure;
  • patients with AV block;
  • with ventricular arrhythmias;
  • if earlier the patient had priapism;
  • in diseases of the liver and kidneys;
  • at the age of 18 years;
  • at parallel reception of MAO inhibitors.

Tablets are taken orally, preferably at bedtime. Sometimes it is advisable to distribute the daily dosage in 3 doses.

The initial dose is 100 mg per day. Further, the dosage can be gradually increased every 3-4 days at 50 mg until the desired therapeutic effect is achieved. The maximum daily dosage is 450 mg. In the hospital it is permissible to use 0.6 grams of a substance per day.


The average maintenance dosage for mild to moderate depression is 0.15 grams per day.

When using the drug as an anxiolytic, 75 mg of a substance is prescribed per day, in 3 doses.

Patients over 65 years old or debilitated patients can be prescribed no more than 0.3 grams of trazodone per day.

For children aged 6 years and over, the daily dosage is calculated from the ratio of 1.5–2 mg of the drug per kg of weight per day. With urgent need, the dose can be increased to 6 mg per kg of body weight per day.


The course of treatment is determined by the attending physician.

In children aged 6 to 18 years with antidepressant treatment requires special caution.

Persons over 65 need to be careful, dosage adjustment may be required.

Due to its well tolerated absence of cholinolytic action, trazodone is widely used in the treatment of elderly patients with organic diseases of the central nervous system, as well as in the complex treatment of patients with somatic diseases complicated by mental disorders (anxiety, tension, etc.).

The drug can not be combined with alcohol.

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